Prevention & lipidsCross-sectional study
Lipoprotein(a) levels in children with hypercholesterolaemia
- Cross-sectional study
- universal or cascade familial hypercholesterolemia (FH) screening, Slovenia
Authors' conclusion
One in four children with FH and one in three children with polygenic hypercholesterolemia have elevated Lp(a) levels, contributing notably to LDL-C levels and ApoB.
Study context
- Population
- Children (median age 6.34 years) with hypercholesterolaemia identified by universal or cascade FH screening in Slovenia
- Participants
- 1,418 children
- Exposure
- Definite FH vs possible FH vs definite non-FH
- Definite FHn = 363
- Possible FHn = 1,014
- Definite non-FHn = 41
- Outcome
- Role and impact of Lp(a) on LDL-C
Main finding
As reported in the abstract
Elevated Lp(a) (>30 mg/dL)
P = 0.003
- Definite FH: Lp(a) contribution to low-density lipoprotein cholesterol (LDL-C) levels
- 32.7%
- Definite FH: Lp(a) contribution to ApoB
- 18.6%
- Lp(a) component of LDL-C, range
- 0-49.6%
- LDL-C variability accounted for by Lp(a)
- 10.3%
Observational data: associations, not effects.
Further findings
| Outcome | Definite FH | Possible FH | Definite non-FH |
|---|---|---|---|
| Elevated LDL-C (>3.5 mmol/L) after adjusting for Lp(a) | 88.4% | 30.4% | Not reported in the abstract |
Original publication
Lipoprotein(a) levels in children with hypercholesterolaemia. Eur J Prev Cardiol. Published 24 February 2026. doi:10.1093/eurjpc/zwag126
Summarised from the published abstract; every number is checked against it