The impact of lipid apheresis on changes of lipoprotein(a): a systematic review and meta-analysis
Pooled result · Serum Lp(a)Result — go to the resultSMD −1.52 95% CI −1.76 to −1.29Authors' conclusion
Lipid apheresis is effective in significantly lowering serum Lp(a) concentrations across a range of patient groups and treatment modalities.
Study context
- Population
- Participants undergoing lipid apheresis in a wide array of disorders, particularly CVD43 publications
- Participants
- 2,466 participants67 studies
- Comparison
- Post- vs pre-lipid apheresis Lp levels
- Outcome
- Change in serum Lp(a) levels
Methodological detailsrandom-effects model, subgroup and meta-regression analyses
- Random-effects model
- Subgroup and meta-regression analyses
Pooled result
Serum Lp(a)
SMD
−1.52
95% CI −1.76 to −1.29
P < 0.001
Post-apheresisvs Pre-apheresis
SMD −1.52 (95% CI −1.76 to −1.29); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Serum Lp(a), one-session lipid apheresis studies (n = 6) | −1.51 (−1.72 to −1.29) | P < 0.001 | |
| −2−101Difference (linear scale) |
Subgroups by Lp(a) detection method, disease background and initial Lp(a)
- Significant reductions across subgroups
Sources of heterogeneity (meta-regression)
- Publication year and disease background contributed to heterogeneity
Original publication
The impact of lipid apheresis on changes of lipoprotein(a): a systematic review and meta-analysis. Eur J Prev Cardiol. Published 24 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →