Valvular & structural heart diseaseCohort study
Liver-related outcomes in patients with tricuspid regurgitation
- Retrospective cohort study
Authors' conclusion
Significant TR is associated with incident cirrhosis, with risk varying by aetiology. The development of cirrhosis portends a worse survival
Study context
- Population
- Adults with documented tricuspid regurgitation (TR) severity without prevalent liver disease, 2004–20227,226 (17.3%) ≥moderate TR
- Participants
- 41,950 adults
- Exposure
- TR severity and liver-related outcomes
- Outcome
- Liver-related outcomes: cirrhosis, hepatocellular carcinoma (HCC) and liver-related death
- Follow-up
- Median 6.4 years
Main finding
As reported in the abstract
Incidence in ≥moderate TR (per 1000 person-years)
Cirrhosis incidence, ≥moderate TR
4.54 (95% CI 3.89-5.29) per 1000 person-years
Hepatocellular carcinoma (HCC) incidence, ≥moderate TR
1.25 (95% CI 0.92-1.68) per 1000 person-years
Liver-related death incidence, ≥moderate TR
1.33 (95% CI 0.99-1.77) per 1000 person-years
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Cirrhosis by TR aetiology (≥moderate TR) — Ventricular TR vs Atrial TR | 2.33 (1.22–4.43) | P = 0.009 | |
| Cirrhosis by TR aetiology (≥moderate TR) — Lead-associated TR vs Atrial TR | 2.66 (1.16–6.09) | P = 0.02 | |
| 0.10.31310Hazard ratio (log scale) |
Predictors of cirrhosis in ≥moderate TR
- Independent predictors: HFpEF, RV dysfunction, cholestatic liver injury
Survival impact of incident cirrhosis (≥moderate TR)
- Incident cirrhosis increased all-cause and CV death risks
Original publication
Liver-related outcomes in patients with tricuspid regurgitation. Eur J Heart Fail. Published 24 March 2026. doi:10.1093/ejhf/xuag057
Summarised from the published abstract; every number is checked against it