Incidence, Predictors and Outcomes of Bleeding Following Transcatheter Tricuspid Valve Repair: The TriValve Registry

Dykun, I; Russo, G; Mahabadi, AA; Thiele, H; Alessandrini, H; Andreas, M; Connelly, KA; Estevez-Loureiro, R; Hahn, RT; Maisano, F; Hausleiter, J; Rassaf, T; Himbert, D; Latib, A; Monivas, V; Fam, N; Pedrazzini, G; Adamo, M; Sievert, H; Webb, JG; Tang, GHL; Stolz, L; Lurz, P; Benito-Gonzalez, T; Taramasso, M; Puri, R

doi:10.1016/j.jcin.2026.01.288

Valvular & structural heart disease

Incidence, Predictors and Outcomes of Bleeding Following Transcatheter Tricuspid Valve Repair: The TriValve Registry

JACC Cardiovasc IntervPublished 23 Mar 2026Retrospective analysis of an international multicentre registry

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Authors' conclusion

BARC major bleeding occurs in about 11% of patients following transcatheter tricuspid valve repair and is a major determinant of in-hospital and 1-year death.

Study context

Population: Patients undergoing transcatheter tricuspid valve repair (TriValve registry)
Participants: 440 patients

Exposure: Major bleeding vs no major bleeding
Outcome: BARC bleeding (types 2, 3 and 5), its predictors and prognostic implications
Follow-up: Within 1 year

Main finding

As reported in the abstract

BARC major bleeding incidence

Bleeding Academic Research Consortium (BARC) major bleeding incidence (50 patients)

11.4%

Observational data: associations, not effects.

Further findings

Predictors of BARC major bleeding · within 1 year

	← Lower odds ←→ Higher odds →	Adjusted OR (95% CI)	P value
Postprocedural tricuspid regurgitation severity	0.20.5125	1.83 (1.12–3.01)	P = 0.02
Higher systolic pulmonary artery pressures	0.20.5125	1.61 (1.16–2.24)	P = 0.0048
Increasing procedure duration	0.20.5125	1.49 (1.00–2.22)	P = 0.049
Concomitant oral anticoagulationNot associated with bleeding	0.20.5125	1.51 (0.74–3.10)	P = 0.30
	0.20.5125Adjusted odds ratio (log scale)

Outcomes associated with bleeding

	← Lower risk ←→ Higher risk →	Adjusted HR (95% CI)	P value
Bleeding1-year death or all-cause hospital readmission	0.10.31310	2.41 (1.39–4.19)	P = 0.002
BleedingAll-cause death	0.10.31310	3.55 (1.75–7.21)	P = 0.0004
BleedingCV death	0.10.31310	3.72 (1.62–8.52)	P = 0.002
	0.10.31310Adjusted hazard ratio (log scale)

Outcome	Adjusted OR (95% CI)	P value
Outcomes associated with bleedingMajor bleeding · in-hospital death	106 (1.31–8,553)	P = 0.04

Original publication

Incidence, Predictors and Outcomes of Bleeding Following Transcatheter Tricuspid Valve Repair: The TriValve Registry. JACC Cardiovasc Interv. Published 23 March 2026. doi:10.1016/j.jcin.2026.01.288

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