Long-Term and Temporal Relationships Between Post-Stent Fractional Flow Reserve and Clinical Outcomes
Main finding · TVFResult — go to the resultAdjusted hazard ratio 1.95 95% CI 1.46–2.62Authors' conclusion
The prognostic impact of post-PCI FFR on TVF persisted over a 5-year follow-up period, but it was more prominent during the first 3 years after PCI. In contrast, its impact on TVR in the nonstented segments was sustained throughout the entire 5-year follow-up period.
Study context
- Population
- Patients after angiographically successful drug-eluting stent implantation with post-PCI fractional flow reserve (FFR) measurement and 5-year follow-upcompleted 5-year follow-up
- Participants
- 2,128 patients
- Exposure
- Low vs high post-PCI FFR
- Outcome
- Target vessel failure (TVF) (cardiac death, target vessel MI, target vessel revascularization (TVR))
- Follow-up
- 5 years
Methodological detailsinternational registry
- International registry
Main finding
TVF
Adjusted hazard ratio
1.95
95% CI 1.46–2.62
P < 0.001
Low post-PCI FFRvs High post-PCI FFR
adjusted HR 1.95 (95% CI 1.46–2.62); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| TVF within and beyond 3 years after PCILow post-PCI FFRvs High post-PCI FFRWithin 3 years | 2.00 (1.44–2.78) | P < 0.001 | |
| TVF within and beyond 3 years after PCILow post-PCI FFRvs High post-PCI FFRAfter 3 years | 1.80 (0.94–3.44) | P = 0.076 | |
| TVR in the nonstented segment · within and beyond 3 yearsLow post-PCI FFRvs High post-PCI FFRWithin 3 years | 2.78 (1.43–5.39) | P = 0.003 | |
| TVR in the nonstented segment · within and beyond 3 yearsLow post-PCI FFRvs High post-PCI FFRBeyond 3 years | 6.73 (2.02–22.37) | P = 0.002 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
Long-Term and Temporal Relationships Between Post-Stent Fractional Flow Reserve and Clinical Outcomes. JACC Cardiovasc Interv. Published 8 December 2025. doi:10.
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