Women’s risk of hypertension and cardiovascular disease subtypes by number of cycles of assisted reproductive technologies: a Norwegian registry-linkage study
Authors' conclusion
Although a clear dose-response relationship was not observed, women who underwent ART had an increased risk of CVD, mainly driven by thromboembolism.
Study context
- Population
- Women in Norway born 1965–2000, alive and residing in Norway on 1 January 200942,763 used assisted reproductive technologies (ART) (cardiovascular disease (CVD) analysis)
- Participants
- 1,625,301 women
- Exposure
- Number of ART cycles vs no ART
- Outcome
- Hypertension and CVD
- Follow-up
- Median 12 years (IQR 10-12)
Methodological detailsregistry linkage, time-varying exposure
- Registry linkage
- Time-varying exposure
Main finding
As reported in the abstract
Risk per additional ART cycle
Each additional ART cycleHazard ratio (95% CI)
CVD
1.07(1.04–1.10)
Hypertension
1.02(1.00–1.04)
Each additional ART cycle, as printed
Observational data: associations, not effects.
Further findings
CVD, ≥4 cycles
| HR (95% CI) | ||
|---|---|---|
| ≥4 cyclesWeak evidence | 1.34 (0.99–1.81) | |
| 0.512Hazard ratio (log scale) |
CVD, programmed frozen cycles
| HR (95% CI) | ||
|---|---|---|
| Programmed frozen cycles | 1.35 (1.18–1.55) | |
| 0.512Hazard ratio (log scale) |
Original publication
Women’s risk of hypertension and cardiovascular disease subtypes by number of cycles of assisted reproductive technologies: a Norwegian registry-linkage study. Eur J Prev Cardiol. Published 3 December 2025. doi:10.
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