Arrhythmias & electrophysiology
Long-term clinical outcomes of patients with drug-induced type 1 Brugada electrocardiographic pattern: A nationwide cohort registry study
Authors' conclusion
In patients with drug-induced type 1 Brugada ECG, the annual risk of life-threatening arrhythmias is low, with the SCN5A mutation as the only independent predictor.
Study context
- Population
- Patients with drug-induced type 1 Brugada electrocardiogram (ECG), Italy and Switzerland, 1997–2021median follow-up 60.3 months
- Participants
- 606 patients
- Outcome
- Composite of:
- Appropriate ICD therapies
- SCD
Methodological detailsmulticentre, 21 Italian and Swiss hospitals, consecutive patients
- Multicentre
- 21 Italian and Swiss hospitals
- Consecutive patients
Main finding
As reported in the abstract
Life-threatening arrhythmias (appropriate ICD therapies or SCD) · median follow-up 60.3 months (IQR 23.0-122.4)
Patients with life-threatening arrhythmias
19
3.1%
Median annual event rate over 5 years
0.5%
Median annual event rate over 10 years
0.25%
Observational data: associations, not effects.
Further findings
Predictors of the primary outcome
| HR | P value | |
|---|---|---|
| SCN5A mutationOnly predictor | 4.54 | P = 0.002 |
| Unexplained syncopeTrend | 3.85 | P = 0.05 |
Life-threatening arrhythmias in patients asymptomatic at presentation · over 5 years
- Median annual rate, asymptomatic
- 0.24%
- Median annual rate, asymptomatic with inducible VF at programmed ventricular stimulation
- 1.2%
Original publication
Long-term clinical outcomes of patients with drug-induced type 1 Brugada electrocardiographic pattern: A nationwide cohort registry study. Heart Rhythm. Published 18 January 2024. doi:10.
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