Heart failure & cardiomyopathies
Long-Term Cognitive and Brain Morphologic Changes in Chronic Heart Failure: Results of the Cognition.Matters-HF Study
Authors' conclusion
In patients with stable HF patients receiving guideline-directed pharmacologic treatment and regular medical care, the presence of CI did not affect overall and hospitalization-free 6-year survival. The loss of brain parenchyma observed in patients with stable HF did not exceed that of normal ageing.
Study context
- Population
- Patients with stable heart failure (HF) of any aetiology and severity47 with 4 serial magnetic resonance imaging (MRI) scans
- Participants
- 148 patients
- Outcome
- Trajectories of cognitive performance, brain volume and related clinical outcome
- Follow-up
- 6 years
Main finding
As reported in the abstract
median follow-up 69 months (quartiles: 68, 70)
- Cognitive impairment at baseline
- 70%
- CI stable over follow-up, except intensity of attention: age-adjusted t-score 42 (38, 46) to 38 (34, 44)
- P < 0.001
Observational data: associations, not effects.
Further findings
Death and HF hospitalization
- Died
- 29 (20%)
- Hospitalized at least once for worsening HF
- 26 (18%)
- CI not associated with overall survival
- P = 0.290
- CI not associated with hospitalization-free survival
- P = 0.450
Original publication
Long-Term Cognitive and Brain Morphologic Changes in Chronic Heart Failure: Results of the Cognition.Matters-HF Study. ESC Heart Fail. Published 14 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →