Heart failure & cardiomyopathies
Long-Term Cost-Effectiveness of Transcatheter Mitral Valve Repair in HF Patients with Secondary Mitral Regurgitation
Authors' conclusion
MitraClip + guideline-directed medical therapy was cost-effective in heart failure patients with secondary mitral regurgitation in the United Kingdom, Germany, and the United States, but not in mainland China from the perspective of the national healthcare system.
Study context
- Population
- HF patients with secondary mitral regurgitation; healthcare systems of mainland China, UK, Germany and US; base case mean age 72.2 yearsmodel base case
- Comparison
- MitraClip + GDMT vs GDMT alone
- Outcome
- Lifetime incremental cost-effectiveness ratio
- Follow-up
- Lifetime horizon
Methodological detailsdecision + Markov model, two-stage (decision + Markov) model, lifetime horizon, based on 5-year COAPT trial follow-up, probabilistic sensitivity analysis, Health utilities from 5-year COAPT trial follow-up; direct healthcare costs from nationally representative data; future utilities and costs discounted at country-specific rates
- Decision + Markov model
- Two-stage (decision + Markov) model
- Lifetime horizon
- Based on 5-year COAPT trial follow-up
- Probabilistic sensitivity analysis
- Health utilities from 5-year COAPT trial follow-up; direct healthcare costs from nationally representative data; future utilities and costs discounted at country-specific rates
Main finding
As reported in the abstract
Mainland China: incremental QALY gain 0.71; ICER per QALY
¥468 462
UK: incremental QALY gain 0.76; ICER per QALY
£28 910
Germany: incremental QALY gain 0.78; ICER per QALY
€26 045
US: incremental QALY gain 0.78; ICER per QALY
$71 199
Further findings
HF re-hospitalizations · lifetime horizon
- Fewer HF re-hospitalizations per 1000 treated patients with MitraClip
- 829
Probabilistic sensitivity analysis: proportion cost-effective at country-specific willingness-to-pay thresholds
- Mainland China
- 0.2%
- UK
- 59.4%
- Germany
- 99.6%
- US
- 84.7%
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →