Heart failure & cardiomyopathies
Long-Term Impact of Pregnancy on Clinical Outcomes in Individuals With Hypertrophic Cardiomyopathy
Main finding · All-cause mortalityResult — go to the resultAdjusted odds ratio 0.89 95% CI 0.7–1.14Authors' conclusion
Pregnancy in individuals with HCM was not associated with a higher risk of adverse outcomes at long-term follow-up.
Study context
- Population
- Individuals of reproductive age (≥18–45 years) with hypertrophic cardiomyopathy (HCM) diagnosed 2012–20223,399 per matched cohort
- Participants
- 10,936 individuals
- Exposure
- Pregnancy vs no pregnancy in HCM
- Pregnancyn = 3,399
- No pregnancyn = 3,399reference
- Outcome
- All-cause mortality
- Follow-up
- 10-year follow-up
Methodological detailspropensity-score matched, TriNetX research network
- Propensity-score matched
- TriNetX research network
Main finding
As reported in the abstract
Adjusted odds ratio
0.89
95% CI 0.7–1.14
P = 0.37
Pregnancyvs No pregnancy
adjusted OR 0.89 (95% CI 0.7–1.14); P = 0.37
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Adjusted OR (95% CI) | P value | |
|---|---|---|---|
| MACE | 1.02 (0.85–1.22) | P = 0.80 | |
| Arrhythmic events (SCD, appropriate shocks, sustained VT/VF) | 0.93 (0.73–1.18) | P = 0.55 | |
| 0.512Adjusted odds ratio (log scale) |
Outcomes in obstructive HCM (subgroup)
- Findings similar between pregnancy and no pregnancy groups
Original publication
Long-Term Impact of Pregnancy on Clinical Outcomes in Individuals With Hypertrophic Cardiomyopathy. JACC Adv. Published 15 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →