Aortic & peripheral vascular diseaseCohort study
Long-Term Outcome and Prognosis of Noninfectious Thoracic Aortitis
- Retrospective cohort study
- multicentre
Aortitis types: 118 clinically isolated aortitis, 57 giant cell arteritis, 21 Takayasu arteritis, 21 various systemic autoimmune disorders · Surgery indications: asymptomatic aneurysm with critical size n = 152 [70%], aortic dissection n = 28 [13%], symptomatic aortic aneurysm n = 30 [14%]
Authors' conclusion
This multicenter study shows that 82% of noninfectious surgical thoracic aortitis patients will experience a vascular complication within 10 years.
Study context
- Population
- Patients with noninfectious thoracic aortitis undergoing thoracic aorta surgeryof 5,666 with thoracic aorta surgery
- Participants
- 217 patients
- Outcome
- Long-term outcome and prognosis: vascular complications and second vascular procedure
Main finding
As reported in the abstract
- 10-year cumulative incidence of vascular complication
- 82.1% (95% CI: 67.6%-90.6%)
- 10-year cumulative incidence of second vascular procedure
- 42.6% (95% CI: 28.4%-56.1%)
- Aortic arch aortitis and vascular complications (independent association)
- HR 2.08 (95% CI 1.26-3.44; P = 0.005)
- Descending thoracic aortitis and second vascular procedure (independent association)
- HR 2.35 (95% CI 1.11-4.96; P = 0.031)
- Aortic dissection and second vascular procedure (independent association)
- HR 3.08 (95% CI 1.61-5.90; P = 0.002)
- Statins after aortitis diagnosis decreased second vascular procedure
- HR 0.47 (95% CI 0.24-0.90; P = 0.028)
Observational data: associations, not effects.
Further findings
Progression to systemic inflammatory disease (clinically isolated aortitis) · median follow-up 3.9 years
- Developed features of a systemic inflammatory disease
- 19 (16.1%)
Death · median follow-up 3.9 years
- Died
- 35 (16%)
Original publication
Summarised from the published abstract; every number is checked against it