Acute cardiac care & resuscitation
Long-term outcomes among out-of-hospital cardiac arrest survivors with reversible vs. non-reversible causes
Authors' conclusion
Compared to other aetiologies, the presence of a reversible ischaemic cause is associated with improved long-term OHCA outcomes.
Study context
- Population
- Adults with non-traumatic out-of-hospital cardiac arrest (OHCA) surviving to hospital discharge, British Columbia Cardiac Arrest registry, 2009–2016median age 62.8 years
- Participants
- 1,325 adults
- Exposure
- Reversible vs non-reversible OHCA aetiologies
- Reversible ischaemicn = 431
- Non-reversible ischaemicn = 415
- Reversible non-ischaemicn = 99
- Non-reversible non-ischaemicn = 380reference
- Outcome
- Composite of:
- All-cause mortality
- Recurrent OHCA
- Re-hospitalization for sudden cardiac arrest or ventricular arrhythmias
Methodological detailsregistry-based
- Registry-based
Main finding
As reported in the abstract
Composite outcome
Each group vs non-reversible non-ischaemicHazard ratio (95% CI)
Reversible ischaemicmultivariate
0.52(0.33–0.81)
Reversible non-ischaemicmultivariate
1.53(1.03–2.32)
Non-reversible ischaemicmultivariate; non-significant
0.92(0.64–1.33)
Observational data: associations, not effects.
Further findings
| Outcome | Reversible ischaemic | Reversible non-ischaemic |
|---|---|---|
| Kaplan-Meier event-free rate · 3 years post discharge | 91% (95% CI 87–94%) | 62% (95% CI 51–72%) |
- Kaplan-Meier event-free rate: highest in reversible ischaemic, lowest in reversible non-ischaemic
Original publication
Long-term outcomes among out-of-hospital cardiac arrest survivors with reversible vs. non-reversible causes. Eur Heart J Acute Cardiovasc Care. Published 29 August 2024. doi:10.
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