Valvular & structural heart disease
Long-term outcomes and durability of balloon-expandable transcatheter aortic valve implantation (TAVI) in small and large annuli
Main findingResult — go to the resultHazard ratio 1.07 95% CI 0.85–1.36Authors' conclusion
Annular size differences were not found to influence long-term outcomes or valve durability following TAVI with a BE-THV, suggesting that other factors warrant further investigation.
Study context
- Population
- Patients who underwent TAVI with a balloon-expandable transcatheter heart valve at least 5 years earlier66.4% small aortic annulus (SAA)
- Participants
- 2,699 patients
- Exposure
- Small vs large aortic annulus after balloon-expandable TAVI
- SAAn = 1,793
- Outcome
- All-cause mortality and bioprosthetic valve failure (BVF)
- Follow-up
- 7 years after TAVI
Main finding
As reported in the abstract
7 years
Hazard ratio
1.07
95% CI 0.85–1.36
P = 0.56
By group
SAA
- Cumulative all-cause mortality
- 55.2%
- Bioprosthetic valve failure (BVF)
- 3.3%
Large aortic annuli (LAA)
- Cumulative all-cause mortality
- 58.6%
- BVF
- 2.7%
Cumulative all-cause mortality
SAA55.2%
Large aortic annuli (LAA)58.6%
Bioprosthetic valve failure (BVF)
SAA3.3%
Large aortic annuli (LAA)2.7%
SAAvs LAA
HR 1.07 (95% CI 0.85–1.36); P = 0.56
Observational data: associations, not effects.
Further findings
Mortality and BVF by postprocedural mean pressure gradient (mPG) ≥20 mmHg, severe prosthesis-patient mismatch (PPM) or sex (subanalysis)
- No significant differences between SAA and LAA
- P > 0.05
Original publication
Long-term outcomes and durability of balloon-expandable TAVI in small and large annuli. EuroIntervention. Published 14 November 2025. doi:10.
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