Heart failure & cardiomyopathies
Rates and Predictors of Cardiovascular and Non-Cardiovascular Outcomes in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
In a clinical cohort hospitalized and diagnosed with HFpEF, death and hospitalization rates were roughly similar for CV and non-CV causes. CV deaths were predicted primarily by severity of HF; non-CV deaths primarily by anaemia and prior stroke. Lower serum sodium predicted both. Hospitalizations were difficult to predict.
Study context
- Population
- Patients hospitalized and diagnosed with HFpEF (EF ≥45%), Karolinska-Rennes study
- Participants
- 539 patients
- Outcome
- Rates and predictors of CV and non-CV death and hospitalization
Methodological detailsbi-national, observational
- Bi-national
- Observational
Main finding
As reported in the abstract
1196 patient-years; median 744 days (13-1959)
- All-cause deaths
- 159 (29%); 13 per 100 patient-years
- Cardiovascular (CV) death
- 5.1 per 100 patient-years
- Heart failure (HF) death
- 3.9 per 100 patient-years
- Non-CV death
- 5.8 per 100 patient-years
- Cancer death
- 2.3 per 100 patient-years
- Hospitalizations (723 in 338 patients, 63%)
- 60 per 100 patient-years
- CV hospitalization
- 33 per 100 patient-years
- HF hospitalization
- 17 per 100 patient-years
- Non-CV hospitalization
- 27 per 100 patient-years
- Lung disease hospitalization
- 5 per 100 patient-years
Observational data: associations, not effects.
Original publication
Rates and Predictors of Cardiovascular and Non-Cardiovascular Outcomes in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 29 July 2024. doi:10.
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