Valvular & structural heart diseaseCohort study
Long-Term Outcomes in Patients With New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Replacement (TAVR)
- Prospective cohort study
- consecutive patients
Authors' conclusion
NOP-LBBB following TAVR was associated with adverse long-term outcomes, including cardiovascular mortality, sudden death, and progressive left ventricular dysfunction.
Study context
- Population
- Consecutive TAVR patients without preprocedural LBBB or permanent pacemaker
- Participants
- 1,052 patients
- Exposure
- New-onset persistent left bundle branch block (NOP-LBBB) vs no NOP-LBBB after TAVR
- NOP-LBBBn = 312
- Outcome
- Composite of:
- CV mortality
- HF hospitalization
- Follow-up
- Median 5 years (Q1-Q3: 3-6 years)
Main finding
CV mortality or HF hospitalization
Adjusted hazard ratio
1.37
95% CI 1.09–1.73
P = 0.007
By group
NOP-LBBB vs No NOP-LBBB
adjusted HR 1.37 (95% CI 1.09–1.73); P = 0.007
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | NOP-LBBB | No NOP-LBBB | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| CV mortality | 30.5% | 23.8% | 1.46 (1.12–1.89) | P = 0.004 | |
| Sudden death | 4.2% | 1.5% | 3.52 (1.53–8.14) | P = 0.003 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
LVEF decline (≥10%)
- Higher incidence with NOP-LBBB
- P = 0.025
HF hospitalization
- No difference between groups
- P = 0.243
Original publication
Long-Term Outcomes in Patients With New-Onset Left Bundle Branch Block Following TAVR. JACC Cardiovasc Interv. Published 11 May 2026. doi:10.1016/j.jcin.2026.03.010
Summarised from the published abstract; every number is checked against it