Heart failure & cardiomyopathies
Long-Term Outcomes of Phenoclusters in Preclinical Heart Failure with Preserved and Mildly Reduced Ejection Fraction
Main finding · HF/deathResult — go to the resultAdjusted hazard ratio 2.46 95% CI 1.24–4.90Authors' conclusion
Based on phenomapping, older patients with lower kidney function and worse diastolic function might represent a subset of preclinical HF with EF > 40% who deserve more efforts to prevent clinical HF.
Study context
- Population
- Asymptomatic outpatients with ejection fraction (EF) > 40% with hypertension, DM or known CVD (preclinical heart failure (HF); DAVID-Berg study)591 in cluster analysis
- Participants
- 596 outpatients
- Exposure
- Phenoclusters: Cluster 3 vs Clusters 1 and 2
- Outcome
- Composite of HF/death
- Follow-up
- Median 5.7 years
Methodological detailsunsupervised cluster analysis (phenomapping)
- Unsupervised cluster analysis (phenomapping)
Main finding
HF/death
Adjusted hazard ratio
2.46
95% CI 1.24–4.90
Cluster 3vs Cluster 1
adjusted HR 2.46 (95% CI 1.24–4.90)
As reported in the abstract
- Subjects with HF/death events, overall (N = 79)
- 13.4%
Observational data: associations, not effects.
Original publication
Long-Term Outcomes of Phenoclusters in Preclinical Heart Failure with Preserved and Mildly Reduced Ejection Fraction. ESC Heart Fail. Published 4 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →