Cohort study
Long-term outcomes of phenoclusters in severe tricuspid regurgitation
- Retrospective cohort study
- single-centre
- consecutive patients
- survival tree modelling
Authors' conclusion
Patients with newly identified severe TR have high 5-year risk for death and death or heart failure hospitalization. Partitioning patients using supervised survival tree models, but not TR etiology, discriminated clinical risk.
Study context
- Population
- Patients with new severe tricuspid regurgitation (TR) by echocardiography (ASE four-category grading), large US tertiary referral centre, 2007–2018; median age 70 years, 61% female, 40% black
- Participants
- 2,379 consecutive patients
- Exposure
- TR etiology and survival-tree phenoclusters
- Outcome
- Death and the composite of death or HF hospitalization
- Follow-up
- 5 years
Main finding
As reported in the abstract
Death; death or HF hospitalization
Death rate
30.9 events/100 patient-years (95% CI 29.0-32.8)
Death or HF hospitalization rate
49.0 events/100 patient-years (95% CI 45.9-52.2)
Observational data: associations, not effects.
Further findings
Survival-tree phenoclusters
- Discriminating variables for both outcomes: age, albumin, blood urea nitrogen, RV function, SBP
- all P < 0.05
- Two separate groups of four phenoclusters with distinct prognoses identified for death and for the composite endpoint
Original publication
Long-term outcomes of phenoclusters in severe tricuspid regurgitation. Eur Heart J. Published 16 March 2023. doi:10.1093/eurheartj/ehad133
Summarised from the published abstract; every number is checked against it