Long-term outcomes of recurrent myocardial infarction: a nationwide Danish study
Main finding · 5-year mortalityResult — go to the resultSummary relative risk 0.78 CI 0.74–0.82Authors' conclusion
Mortality has decreased in parallel with intensified pharmacologic and invasive management of patients with recurrent MI. However, there has been little improvement in heart failure hospitalisations, underscoring that directed preventive strategies are needed to mitigate the heart failure risk in patients with recurrent MI.
Study context
- Population
- All patients with first-time recurrent myocardial infarction (MI) in Denmark during 2003 to 2022patients with recurrent MI
- Participants
- 24,799 patients
- Exposure
- Outcomes of recurrent MI in 2018-2022 vs 2003 to 2007
- 2003 and 2007n = 7,368
- 2018-2022n = 4,928
- Outcome
- 5-year mortality
- Follow-up
- 5-year
Main finding
As reported in the abstract
Summary relative risk
0.78
CI 0.74–0.82
By group
2018-2022vs 2003 and 2007
sRR 0.78 (CI 0.74–0.82)
Observational data: associations, not effects.
Further findings
| Outcome | 2003 and 2007 | 2018-2022 | sRR (CI) | |
|---|---|---|---|---|
| 5-year incidence of HHF | 13.6% | 11.7% | 0.76 (0.68–0.84) | |
| 5-year incidence of subsequent recurrent MI | 23.4% | 17.7% | 0.65 (0.52–0.78) | |
| 0.512Summary relative risk (log scale) |
Baseline characteristics and management over time
- Lipid-lowering treatment at baseline
- 53.7% to 76.6%
- Coronary angiogram
- 41.2% to 77.4%
- Percutaneous coronary intervention
- 26.8% to 54.0%
- Median age decreased from 75 to 73 years
- The prevalence of non-cardiovascular comorbidities increased
5-year incidence of hospitalisation for heart failure (HHF), stratified analyses
- HHF increased in patients with previous HF
- 23.9% to 26.2%
- HHF increased in males aged ≥75 years
- 14.3% to 15.9%
- Mortality and subsequent recurrent MI decreased consistently across subgroups
- Stratified analyses
Original publication
Long-term outcomes of recurrent myocardial infarction: a nationwide Danish study. Eur Heart J Acute Cardiovasc Care. Published 1 August 2025. doi:10.
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