Long-term prognosis of low high-sensitivity cardiac troponin T in the emergency department compared with the general population
Authors' conclusion
Patients with chest pain and undetectable hs-cTnT have an overall lower risk of death compared with the general population, with risks being highly age dependent. Detectable hs-cTnT concentrations are still associated with increased long-term cardiovascular risks.
Study context
- Population
- Patients presenting to the emergency departments (ED) with chest pain and ≥1 hs-cTnT measured, without myocardial injury (any hs-cTnT >14 ng/L), Sweden, 2010–2017
- Exposure
- Low (5-14 ng/L) vs undetectable (<5 ng/L) peak hs-cTnT; undetectable hs-cTnT vs general population
- Undetectable hs-cTnTn = 69,090reference
- Low hs-cTnTn = 42,826
- Outcome
- All-cause mortality and MACE (acute myocardial infarction (MI), HF hospitalisation, stroke or CV death); Standardised mortality ratios (SMRs) and standardised incidence ratios (SIRs) vs general population
Methodological detailsmulticentre, 7 Swedish EDs
- Multicentre
- 7 Swedish EDs
Main finding
As reported in the abstract
Estimate (95% CI)
Undetectable hs-cTnTvs General Swedish populationfuture MI
SIR 1.39(1.32–1.47)
Low hs-cTnTvs Undetectable hs-cTnTadjusted; first MACE
HR 1.61(1.53–1.70)
- Undetectable hs-cTnT vs General Swedish population · mortality; lower risks in all patients ≥65 years
- SMR 0.83 (95% CI 0.79–0.87)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Long-term prognosis of low high-sensitivity cardiac troponin T in the emergency department compared with the general population. Heart. Published 7 June 2024. doi:10.
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