Valvular & structural heart disease
Long-Term Prognostic Value of the H2FPEF Score in Patients Undergoing Transcatheter Aortic Valve Implantation
Authors' conclusion
The H2FPEF score is useful for predicting long-term adverse outcomes after TAVI, including all-cause mortality, cardiovascular mortality, and HF hospitalization for patients with preserved EF.
Study context
- Population
- Patients with preserved ejection fraction (EF) ≥ 50% undergoing transcatheter aortic valve implantation (TAVI), October 2013 to May 2017median age 85 years, 72% female
- Participants
- 1,674 patients
- Exposure
- High vs low H2FPEF score
- Low H2FPEF scoren = 1,399reference
- High H2FPEF scoren = 275
- Outcome
- All-cause mortality, CV mortality, HF hospitalization and composite of CV mortality and HF hospitalization
- Follow-up
- 2 years
Methodological detailsmulticentre, Japanese registry (OCEAN-TAVI)
- Multicentre
- Japanese registry (OCEAN-TAVI)
Main finding
As reported in the abstract
Cumulative 2-year outcomes
High H2FPEF score
- All-cause mortality
- 26.3%
- CV mortality
- 10.5%
- Heart failure (HF) hospitalization
- 16.2%
- CV mortality and HF hospitalization
- 23.8%
Low H2FPEF score
- All-cause mortality
- 15.5%
- CV mortality
- 5.4%
- HF hospitalization
- 6.7%
- CV mortality and HF hospitalization
- 10.8%
All-cause mortality
High H2FPEF score26.3%
Low H2FPEF score15.5%
CV mortality
High H2FPEF score10.5%
Low H2FPEF score5.4%
Heart failure (HF) hospitalization
High H2FPEF score16.2%
Low H2FPEF score6.7%
CV mortality and HF hospitalization
High H2FPEF score23.8%
Low H2FPEF score10.8%
High H2FPEF score vs Low H2FPEF scoreAdjusted hazard ratio (95% CI)P value
All-cause mortality
1.48(1.09–2.00)
P = 0.011CV mortality and HF hospitalization
1.95(1.38–2.74)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| CV mortality and HF hospitalization, by STS score (subgroup)High H2FPEF scorevs Low H2FPEF scoreSTS score <8% | 2.40 (1.50–3.85) | P < 0.001 | |
| CV mortality and HF hospitalization, by STS score (subgroup)High H2FPEF scorevs Low H2FPEF scoreSTS score ≥8% | 1.34 (0.79–2.28) | P = 0.28 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- CV mortality and HF hospitalization, by Society of Thoracic Surgeons (STS) score (subgroup): Pinteraction = 0.030
Original publication
Long-Term Prognostic Value of the H2FPEF Score in Patients Undergoing Transcatheter Aortic Valve Implantation. ESC Heart Fail. Published 12 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →