Valvular & structural heart disease
Pacemaker implantation rate after transcatheter aortic valve implantation with early and new-generation devices: a systematic review
Authors' conclusion
The rate of PPI after TAVI with new-generation devices is highly variable.
Study context
- Population
- Patients undergoing transcatheter aortic valve implantation (TAVI); original articles published October 2010–October 2017
- Participants
- 17,139 patients40 studies
- Comparison
- New-generation vs early generation TAVI prostheses
- Outcome
- Incidence of permanent pacemaker implantation (PPI) after TAVI with new-generation devices
Methodological detailsPRISMA
- PRISMA
Pooled result
As reported in the abstract
PPI rate
Permanent pacemaker implantation (PPI) after any new-generation TAVI prosthesis, range
2.3% and 36.1%
Further pooled results
Female sex, highest (>26.0%) vs lowest (<12.1%) quintile of PPI rate
P < 0.001
Factors associated with PPI
- Pre-existent conduction abnormalities, LV outflow tract calcification, balloon valvuloplasty and implantation depth associated with increased PPI risk
Original publication
Pacemaker implantation rate after transcatheter aortic valve implantation with early and new-generation devices: a systematic review. Eur Heart J. Published 6 February 2018. doi:10.
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