Arrhythmias & electrophysiologyCohort study
Long-term rate of ventricular arrhythmia in autoimmune disease
- Matched cohort study
- nationwide registries
- matched by age and sex
Authors' conclusion
Despite a low cumulative incidence, patients with a history of AIDs had a higher relative rate of VAs than matched individuals.
Study context
- Population
- Individuals with autoimmune disease, Danish nationwide registries, 2005–18median follow-up 6.0 years
- Participants
- 186,733 vs 746,932
- Exposure
- Autoimmune disease vs matched background population
- Autoimmune diseases (AIDs)n = 186,733
- Matched individualsn = 746,932reference
- Outcome
- Ventricular arrhythmias (composite of VT, VF, ventricular flutter or cardiac arrest)
- Follow-up
- Median 6.0 years
Main finding
Ventricular arrhythmias
Hazard ratio
1.39
95% CI 1.29–1.49
By group
AIDs vs Matched individuals
HR 1.39 (95% CI 1.29–1.49)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Ventricular arrhythmias, systemic sclerosis · highest HR among individual AIDs | 3.86 (1.92–7.75) | |
| 0.10.31310Hazard ratio (log scale) |
Ventricular arrhythmias, by ischaemic heart disease or HF/cardiomyopathy (subgroup)
- Higher rate with AIDs more pronounced in patients without ischaemic heart disease or HF/cardiomyopathy
- P for interaction < 0.05
- interaction P <0.05
Original publication
Long-term rate of ventricular arrhythmia in autoimmune disease. Eur J Prev Cardiol. Published 28 March 2024. doi:10.1093/eurjpc/zwae118
Summarised from the published abstract; every number is checked against it