Coronary disease & ACSCross-sectional study
Coronary Atherosclerosis in Liver Transplant Recipients and Population Controls
- Cross-sectional study
- age- and sex-matched 1:5
Authors' conclusion
LTx recipients had a significantly higher prevalence and severity of coronary atherosclerosis compared with matched general population control subjects, after adjusting for traditional cardiovascular risk factors.
Study context
- Population
- Liver transplant recipients aged ≥40 years and matched population controls, protocolized research coronary CT angiography
- Participants
- 205 vs 1,025
- Exposure
- LTx recipients vs population controls
- LTx recipientsn = 205
- Population controlsn = 1,025reference
- Outcome
- Prevalence and severity of coronary atherosclerosis (any, obstructive ≥50% stenosis, extensive >5 coronary segments) on coronary CT angiography
Main finding
As reported in the abstract
Coronary atherosclerosis
LTx recipients
63%
Any · Obstructive 18% · Obstructive-extensive 13%
Population controls
46%
Any · Obstructive 10% · Obstructive-extensive 6%
LTx recipients vs Population controlsOdds ratio (95% CI)
any coronary atherosclerosis, adjusted
2.19(1.48–3.27)
obstructive, adjusted
2.73(1.43–5.16)
obstructive-extensive, adjusted
3.90(1.76–8.55)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| High-risk plaque (among those with any coronary atherosclerosis) | 2.10 (1.29–3.45) | |
| 0.20.5125Odds ratio (log scale) |
SCORE2 risk
- Did not differ significantly
- P = 0.20
Original publication
Coronary Atherosclerosis in Liver Transplant Recipients and Population Controls. J Am Coll Cardiol. Published 4 March 2026. doi:10.1016/j.jacc.2026.01.041
Summarised from the published abstract; every number is checked against it