Long-Term Systolic Blood Pressure Time in Target Range and Cardiovascular Disease in Individuals With Hypertension
Authors' conclusion
A greater percentage of SBP-TTR was associated with a lower risk of CVD among patients with hypertension. These findings underscore the importance of maintaining SBP within the target range for the prevention of CVD among hypertensive individuals.
Study context
- Population
- Hypertensive patients free of cardiovascular disease (CVD) at baseline from the Kailuan Studyhypertensive patients (mean age 52.8 ± 10.7 years, 83.1% males)
- Participants
- 26,929 patients
- Exposure
- Comparing the high systolic blood pressure time in target range (SBP-TTR) with the low SBP-TTR group
- Outcome
- Incident CVD, myocardial infarction and stroke
- Follow-up
- Median 8.6 years
Main finding
As reported in the abstract
high SBP-TTR vs low SBP-TTRMultivariable hazard ratio (95% CI)
CVD
0.67(0.59–0.76)
Myocardial infarction
0.76(0.56–1.02)
Stroke
0.64(0.56–0.74)
- CVD cases
- 2,565
- Myocardial infarction cases
- 472
- Stroke cases
- 2,151
Observational data: associations, not effects.
Further findings
Association between SBP-TTR and CVD risk by age
- Stronger among individuals aged <65 years than their older counterparts
- P for interaction <0.001
Original publication
Long-Term Systolic Blood Pressure Time in Target Range and Cardiovascular Disease in Individuals With Hypertension. JACC Adv. Published 16 April 2025. doi:10.
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