Association Between Systolic Blood Pressure Time in Target Range Indices and Adverse Cardiovascular Outcomes
Primary result · MACE per SD increase in 3-month TTR 110-140 mm HgResult — go to the resultHazard ratio 0.898 95% CI 0.788–1.022Authors' conclusion
In nondiabetic hypertensive patients, the 3-month TTR 110 to 140 mm Hg index was independently associated with 2-year MACEs.
Study context
- Population
- SPRINT participants with complete systolic blood pressure (SBP) records, excluding those with events in the initial 2 years280 with MACE
- Participants
- 7,134 participants
- Comparison
- SBP time in target range indices and MACE
- Primary endpoint
- MACE:
- Heart attack
- Stroke
- HF
- CV death
Primary result
As reported in the abstract
MACE per SD increase in 3-month TTR 110-140 mm Hg · median follow-up 3.91 years
Hazard ratio
0.898
95% CI 0.788–1.022
3-month TTR 110-140 (per SD increase)
HR 0.898 (95% CI 0.788–1.022)
Per SD increase, as printed
Further findings
MACE by mean SBP subgroups, good early control (3-month time in target range (TTR) >0.65)
- No difference in MACE between mean SBP subgroups
- P = 0.88
- Cutoff 0.65 identified by threshold saturation analysis
MACE by mean SBP subgroups, poor early control (3-month TTR ≤0.65)
- Higher mean SBP of 130 to 140 mm Hg related to increased MACE risk
- P = 0.019
Original publication
Association Between Systolic Blood Pressure Time in Target Range Indices and Adverse Cardiovascular Outcomes. JACC Adv. Published 18 October 2024. doi:10.
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