Long-Term Trajectories of Left Heart Geometry, Mechanics, and Oxygen Demand After Bariatric Surgery
Authors' conclusion
Bariatric surgery results in favorable 5-year trajectories of LV geometry, myocardial O 2 demand, and left heart longitudinal mechanics. However, suboptimal postoperative body mass index and blood pressure control promote long-term LV structural disease.
Study context
- Population
- Patients undergoing Roux-en-Y gastric bypasspatients evaluated preoperatively, 6 months, and 1 and 5 years after surgery
- Participants
- 102 patients
- Exposure
- Left heart geometry, mechanics and myocardial O 2 demand before vs 5 years after Roux-en-Y gastric bypass
- Outcome
- LV mass index, global longitudinal strain, myocardial oxygen demand, left atrial emptying fraction
- Follow-up
- 63 (interquartile range, 62-66) months
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
- Left ventricular (LV) mass index, global longitudinal strain, myocardial oxygen demand, and left atrial emptying fraction were improved
- P <0.001
Observational data: associations, not effects.
Further findings
Prevalence of normal LV geometry
- Prevalence of normal LV geometry increased from
- 61% to 82%
Determinants of improving global longitudinal strain and myocardial O 2 demand over time (linear mixed-effects models)
- Associated with female sex and lower body mass index
- P < 0.05
- Adjustment for clinical characteristics
5-year presence of abnormal LV geometry, low LV global longitudinal strain, or high myocardial O 2 demand (logistic regression)
- Related to preoperative diabetes, hypertension, and higher body mass index, as well as higher 5-year systolic blood pressure
- P < 0.05
- Nagelkerke R 2
- 0.40
Original publication
Long-Term Trajectories of Left Heart Geometry, Mechanics, and Oxygen Demand After Bariatric Surgery. Circ Heart Fail. Published 7 April 2025. doi:10.
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