HypertensionRandomised controlled trial
Randomized Trial of Effect of Bariatric Surgery on Blood Pressure After 5 Years
- Randomised controlled trial
Authors' conclusion
Bariatric surgery represents an effective and durable strategy to control hypertension and related polypharmacy in subjects with obesity.
Study context
- Population
- Obesity grade 1 or 2 plus hypertension on at least 2 medications; excluding previous CV events and poorly controlled T2DM
- Participants
- 100 participants
- Comparison
- RYGB plus medical therapy (MT) vs MT alone
- Primary endpoint
- Reduction of at least 30% of total antihypertensive medications while maintaining BP <140/90 mm Hg
- Follow-up
- 5 years
Primary result
As reported in the abstract
Relative risk
5.91
95% CI 2.58–13.52
P < 0.001
By group
RYGB vs MT
RR 5.91 (95% CI 2.58–13.52); P < 0.001
Further findings
BMI · 5 years
P < 0.001
Mean
| Outcome | RYGB | MT | P value |
|---|---|---|---|
| Number of antihypertensive medications · 5 years | 0.80 (95% CI 0.51–1.09) | 2.97 (95% CI 2.33–3.60) | P < 0.001 |
Hypertension remission · 5 years
- Rates of hypertension remission 2.4% vs 46.9%
- RR 19.66 (95% CI 2.74-141.09); P < 0.001
Apparent resistant hypertension · 5 years
- Lower after RYGB (0% vs 15.2%)
Sensitivity analysis (completed cases only)
- Consistent results
Original publication
Randomized Trial of Effect of Bariatric Surgery on Blood Pressure After 5 Years. J Am Coll Cardiol. Published 13 February 2024. doi:10.1016/j.jacc.2023.11.032
Summarised from the published abstract; every number is checked against it