Heart failure & cardiomyopathies
Longitudinal Blood Pressure and Cardiovascular Outcomes in Heart Failure: An Individual Patient Data Pooling Analysis of Clinical Trials
Authors' conclusion
The relationship between BP and HF outcomes is non-linear and closely tied to left ventricular ejection fraction. Low SBP consistently predicts a poor prognosis, whereas high SBP is associated with an increased risk in HFmrEF and HFpEF but not in HFrEF.
Study context
- Population
- Patients with HF with reduced ejection fraction (HFrEF), HFmrEF or HFpEF in 8 clinical trials
- Participants
- 28,406 patients8 trials
- Comparison
- Low and high systolic BP (SBP) vs middle SBP
- Outcome
- Time to first CV death or heart failure (HF) hospitalization
Methodological detailstime-dependent blood pressure (BP), multivariate Cox regression
- Time-dependent BP
- Multivariate Cox regression
Pooled result
As reported in the abstract
CV death or HF hospitalization
Hazard ratio (95% CI)P value
Low SBPvs Middle SBPHFrEF
1.71(1.60–1.82)
P < 0.001High SBPvs Middle SBPHFrEF
1.07(0.97–1.18)
P = 0.187Low SBPvs Middle SBPHFmrEF and HFpEF
1.74(1.47–2.07)
P < 0.001High SBPvs Middle SBPHFmrEF and HFpEF
1.77(1.45–2.17)
P < 0.001Original publication
Longitudinal Blood Pressure and Cardiovascular Outcomes in Heart Failure: An Individual Patient Data Pooling Analysis of Clinical Trials. Eur J Heart Fail. Published 24 May 2025. doi:10.
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