Cardiometabolic & kidneyCohort study
Loss of Y Chromosome and Cardiovascular Events in Chronic Kidney Disease
- Cohort study
- two cohorts (CARE for HOMe and 4D)
Authors' conclusion
LOY identifies male patients with chronic kidney disease at high risk for mortality and heart failure events.
Study context
- Population
- Men with stable CKD (CARE for HOMe) and dialysis patients (4D)CARE for HOMe n=279
- Exposure
- LOY >17% vs LOY ≤17%
- Outcome
- Mortality, combined CV and HF-specific end points, echocardiographic measures
Main finding
As reported in the abstract
LOY >17% vs LOY ≤17%Hazard ratio (printed as "heart rate") (95% CI)
CARE for HOMe: mortality
2.58(1.33–5.03)
CARE for HOMe: cardiac decompensation or death
2.30(1.23–4.27)
4D: mortality
2.76(1.83–4.16)
4D: death due to HF and SCD
4.11(2.09–8.08)
Observational data: associations, not effects.
Further findings
Echocardiography (CARE for HOMe) · 5 years
- LOY >17%: significant decline of EF and increase of E/E'
Biomarkers and monocytes
- LOY >17%: significantly higher plasma soluble interleukin 1 receptor-like 1 (myocardial fibrosis biomarker)
- LOY >17%: intermediate monocytes with significantly higher CCR2 expression and higher plasma CCL2
Original publication
Loss of Y Chromosome and Cardiovascular Events in Chronic Kidney Disease. Circulation. Published 15 July 2024. doi:10.1161/circulationaha.124.069139
Summarised from the published abstract; every number is checked against it