Association of Gestational Diabetes With Subclinical Cardiovascular Disease
Authors' conclusion
Having GDM within the past decade was associated with more adverse cardiac structure/function and vascular endothelial function. Some, but not all, risks may be mediated through the development of prediabetes or type 2 diabetes.
Study context
- Population
- Women with deliveries in 2008–2009, assessed 8 to 10 years postpartum (average age 38 years)
- Participants
- 254 women
- Exposure
- Prior gestational diabetes mellitus (GDM) vs no GDM
- GDMn = 53
- Outcome
- Adverse cardiac remodeling (echocardiography) and endothelial dysfunction (peripheral arterial tonometry, glycocalyx analysis), independent of T2DM
- Follow-up
- 8 to 10 years postpartum
Main finding
As reported in the abstract
Cardiac structure/function and endothelial function
GDM
- Reactive hyperemia
- 1.58
- Red blood cell filling
- 0.70 ± 0.04
No GDM
- Reactive hyperemia
- 1.95
- Red blood cell filling
- 0.72 ± 0.05
Reactive hyperemia
GDM1.58
No GDM1.95
Red blood cell filling
GDM0.70 ± 0.04
No GDM0.72 ± 0.05
GDM vs No GDMDifference (95% CI)
Greater septal wall thickness; adjusted for demographic and reproductive characteristics
8%(2.3%–14.7%)
Higher E/E'; adjusted for demographic and reproductive characteristics
11%(1.1%–21.5%)
Observational data: associations, not effects.
Further findings
Incident prediabetes or diabetes · 8 to 10 years postpartum
Original publication
Association of Gestational Diabetes With Subclinical Cardiovascular Disease. JACC Adv. Published 12 July 2024. doi:10.
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