Heart failure & cardiomyopathies
Lower Extremity Lymphatic Flow is Associated with Diuretic Response in Acute Heart Failure
Authors' conclusion
For the first time, faster lower limb lymph flow was linked with better diuretic efficacy in AHF.
Study context
- Population
- Acute heart failure (AHF) patients receiving protocolized diuretics, with lower limb lymph flow assessed by indocyanine green lymphangiography
- Participants
- 65 patients
- Exposure
- Diuretic responders vs non-responders
- Respondersn = 43
- Non-respondersn = 22reference
- Outcome
- Lower limb lymph flow
- Follow-up
- Within 10 min of dye injection
Main finding
As reported in the abstract
Lymph flow present
P < 0.01
Lymph flow significant
| Outcome | Responders | Non-responders | P value |
|---|---|---|---|
| Median distance lymph reached | 50 [24-75] cm | 10 [3-38] cm | P < 0.0005 |
- Lymph flow distance independently predicted diuretic efficacy (multivariable OR 1.48, 95% CI 1.08-2.03)
- P < 0.05
- Association of lymph flow with 6-h diuresis, β (SE) 0.45 (0.13)
- P < 0.005
Observational data: associations, not effects.
Original publication
Lower Extremity Lymphatic Flow is Associated with Diuretic Response in Acute Heart Failure. Eur J Heart Fail. Published 7 April 2025. doi:10.
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