Heart failure & cardiomyopathies
Lung Diffusion Capacity Correlates with Pre-Implant Pulmonary Hypertension and Predicts Outcome After Left Ventricle Assist Device (LVAD) Implantation
Authors' conclusion
Before LVAD implantation, DLCO impairment is associated with higher PVR and DPG, suggesting that it might be an expression of persistent pulmonary damage occurring in Cpc-PH. After LVAD implantation, both LV dimension and haemodynamics improve. Lower pre-implant DLCO is associated with better LV reverse remodelling.
Study context
- Population
- Patients with advanced heart failure (HF) implanted with an LVAD35 post-capillary pulmonary hypertension (PH)
- Participants
- 42 patients
- Outcome
- Impact of pre-implant DLCO and central haemodynamics on outcome
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
DLCO inversely correlated with pulmonary vascular resistance (PVR)
P 0.037
DLCO inversely correlated with diastolic pulmonary gradient (DPG)
P 0.042
Lower DLCO and Cpc-PH at baseline associated with better LV reverse remodelling (LVDd)
P 0.027
Lower DLCO and Cpc-PH at baseline associated with smaller gain in pulmonary artery compliance
P 0.049
Observational data: associations, not effects.
Further findings
Post-LVAD vs baseline changes
- Improvement in LV diameter (LVDd)
- P < 0.001
- Improvement in mitral regurgitation
- P 0.022
- mPAP 24 vs. 36 mmHg
- P < 0.001
- PAWP 12 vs. 23 mmHg
- P 0.001
- Pulmonary artery compliance 3.1 vs. 1.9 mL/mmHg
- P 0.021
Original publication
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