Heart failure & cardiomyopathies
Sex-Related Differences in Left Ventricular Assist Device Utilization and Outcomes: Results from the PCHF-VAD Registry
Main finding · All-cause mortalityResult — go to the resultHazard ratio 0.79 95% CI 0.50–1.27Authors' conclusion
In this contemporary European cohort of LVAD patients, far fewer women than men underwent LVAD implantation despite similar clinical outcomes.
Study context
- Population
- Continuous-flow left ventricular assist device (LVAD) patients, contemporary European cohort (PCHF-VAD registry)
- Participants
- 105 vs 457
- Exposure
- Women vs men with continuous-flow LVAD
- Womenn = 105
- Menn = 457reference
- Outcome
- All-cause mortality
Methodological detailsmulticentre, Median follow-up 344 [range 147-823] days (women) vs 435 [range 190-816] days (men), P = 0.40
- Multicentre
- Median follow-up 344 [range 147-823] days (women) vs 435 [range 190-816] days (men), P = 0.40
Main finding
As reported in the abstract
Hazard ratio
0.79
95% CI 0.50–1.27
Femalevs Male
HR 0.79 (95% CI 0.50–1.27)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Ventricular arrhythmiasFemalevs Male | 0.56 (0.33–0.95) | |
| 0.20.5125Hazard ratio (log scale) |
RV failure
- More often in female LVAD patients
Bleeding, thromboembolism, haemocompatibility score
- No significant sex-related differences in other outcomes
Original publication
Sex-Related Differences in Left Ventricular Assist Device Utilization and Outcomes: Results from the PCHF-VAD Registry. ESC Heart Fail. Published 22 December 2022. doi:10.
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