Arrhythmias & electrophysiology

Machine learning prediction of outcome following pulsed-field atrial fibrillation ablation: patient selection and risk factors

EuropacePublished Prospective registry-based prognostic modelling study

Authors' conclusion

This is the first ML model exclusively trained and validated on AF patients undergoing PFA providing actionable insights for personalized treatment planning.

Study context

Population
Consecutive atrial fibrillation (AF) patients undergoing transcatheter pulsed field ablation (PFA) (FARAWAVE catheter), ATHENA registry, June 2022–December 2024
Participants
1,688 patients
Outcome
Arrhythmic recurrence (prediction by ML models)
Follow-up
1 year
Methodological detailsmachine learning, consecutive patients
  • Machine learning
  • Consecutive patients

Performance

As reported in the abstract

Prediction of 1-year arrhythmic recurrence
Test or modelAUC
Random Forest0.75 (95% CI 0.69-0.82)

Random Forest

AUC0.75 (95% CI 0.69-0.82)
Arrhythmic recurrence
314 patients (18.6%)

Original publication

Machine learning prediction of outcome following pulsed-field atrial fibrillation ablation: patient selection and risk factors. Europace. Published 15 May 2026. doi:10.1093/europace/euag053

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