Heart failure & cardiomyopathies
MAgnetic resonance imaging based DUal lead cardiac Resynchronization therapy: A prospectIve Left Bundle Branch Pacing study (MADURAI left bundle branch pacing (LBBP) study)
Authors' conclusion
CMR-guided CRT using LOT-DDD-P seems to be a safe and feasible approach in LB-NICM
Study context
- Population
- Patients with left bundle branch block (LBBB)-associated nonischemic cardiomyopathy, left ventricular ejection fraction (LVEF) ≤35% and heart failure (HF), enrolled 2019–20224 withdrew
- Participants
- 120 patients
- Exposure
- LBBP only vs LBBP + implantable cardioverter-defibrillator (ICD)
- Group In = 105
- Group IIn = 11
- Outcome
- (1) Echocardiographic response (ΔLVEF ≥15%) at 6 months; (2) composite of time to death, HF hospitalization or sustained ventricular tachycardia (VT)/ventricular fibrillation (VF)
Methodological detailsCardiac magnetic resonance (CMR) risk-stratified
- CMR risk-stratified
Main finding
As reported in the abstract
mean follow-up 21 ± 12 months
Values · mean follow-up 21 ± 12 months
Death, HFH or VT/VF
P < 0.0001
- Group I vs Group II: P = 0.0001 — echocardiographic response (68/85 vs 3/11)
Observational data: associations, not effects.
Secondary outcomes
Echocardiographic hyperresponse (LVEF ≥50%) · 3, 6 and 12 months
3 months
6 months
12 months
Original publication
MAgnetic resonance imaging based DUal lead cardiac Resynchronization therapy: A prospectIve Left Bundle Branch Pacing study (MADURAI LBBP study). Heart Rhythm. Published 20 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →