Heart failure & cardiomyopathies
Major Adverse Kidney Events Predict Reduced Survival in Ventricular Assist Device Supported Patients
Main finding · SurvivalResult — go to the resultHazard ratio 4.80Authors' conclusion
MAKE significantly impacts survival. In our cohort, MAKE was predicted by post-implant right ventricular failure and chronic haemolysis.
Study context
- Population
- Patients supported with ventricular assist devices (VAD), 2010–2019median age 56.8 years
- Participants
- 173 patients
- Exposure
- Major adverse kidney events (MAKE) vs no MAKE
- MAKEn = 37
- Outcome
- Association between MAKE and survival
Methodological detailssingle-centre, consecutive VAD implants
- Single-centre
- Consecutive VAD implants
Main finding
Survival
Hazard ratio
4.80
P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Risk factors for MAKE (multivariate)
| Adjusted OR | P value | |
|---|---|---|
| Post-implant clinical RV failure | 9.88 | P < 0.001 |
| Chronic haemolysis (schistocytes on blood film) | 3.33 | P = 0.006 |
Renal trajectory (estimated glomerular filtration rate (eGFR)) · 3 months
- Patients who died or had MAKE did not show the expected transient 3-month eGFR improvement
Original publication
Major Adverse Kidney Events Predict Reduced Survival in Ventricular Assist Device Supported Patients. ESC Heart Fail. Published 15 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →