Heart failure & cardiomyopathies
Cognitive Transitions Based on Functional Status in Older Adults with Heart Failure: A Population-Based Study
Main finding · Cognitive transitions from normal/mild cognitive status at baselineResult — go to the resultHazard ratio 5.24 95% CI 3.47–7.90Authors' conclusion
In older patients with HF, the prevalence of cognitive impairment was always higher for those with reduced functional status. Despite having a normal/mild cognitive status at baseline, patients with dependent ADL are at high risk of experiencing cognitive decline over 24 months with substantially less chance of maintaining their cognitive status. ADL dependency was an important risk factor of cognitive decline in patients with HF.
Study context
- Population
- Patients ≥65 years with ICD-10 code of heart failure (HF), long-term care and medical insurance database, Nobeoka city, rural south-western Japanmean age 82.3 ± 7.9 years
- Participants
- 1,764 patients
- Exposure
- Dependent activities of daily living (ADL) vs independent ADL at baseline
- Dependent ADLn = 485
- Independent ADLn = 1,279reference
- Outcome
- Cognitive transitions (to moderate/severe cognitive status) by ADL status
- Follow-up
- 24 months
Methodological detailspopulation-based, multi-state modelling
- Population-based
- Multi-state modelling
Main finding
As reported in the abstract
Hazard ratio
5.24
95% CI 3.47–7.90
By group
Dependent ADL
47%
Probability of maintaining same cognitive status
Independent ADL
86%
Probability of maintaining same cognitive status
Observational data: associations, not effects.
Further findings
Cognitive status at baseline
- Normal/mild cognitive status
- 1656 (93.9%)
- Moderate/severe cognitive status
- 108 (6%)
- Moderate/severe cognitive status with dependent ADL
- 104 (96%)
- In moderate/severe cognitive status, dependent ADL always outnumbered independent ADL throughout follow-up
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →