Arrhythmias & electrophysiology
Major arrhythmias in non-dilated left ventricular cardiomyopathy: a novel prediction score
Authors' conclusion
In NDLVC, male sex, non-sustained VT, LVEF < 45%, septal and ring-like LGE, high-risk genotypes, and myocardial inflammation predicted the first episode of MAE by 60 months.
Study context
- Population
- Patients with non-dilated LV cardiomyopathy (non-dilated left ventricular cardiomyopathy (NDLVC)) and no history of major arrhythmic eventvalidation cohort n = 216
- Participants
- 337 patients
- Outcome
- First MAE (sustained ventricular tachycardia (VT), VF or appropriate ICD therapy)
- Follow-up
- 60-month follow-up
Methodological detailstwo centres, external validation cohort (11 European centres)
- Two centres
- External validation cohort (11 European centres)
Main finding
As reported in the abstract
First MAE (predictors) · 60 months
Hazard ratio (95% CI)P value
Male sex
2.4(1.3–4.4)
P = 0.007Baseline non-sustained VT
3.1(1.7–5.6)
P < 0.001LVEF < 45%
5.5(2.7–11.0)
P < 0.001Septal LGE
2.0(1.0–4.0)
P = 0.046Ring-like LGE
1.3(.6-2.6)
P = 0.54Pathogenic/likely pathogenic variants in guideline-defined high-risk genes
4.6(2.3–9.1)
P < 0.001Biopsy/CMR-proven myocardial inflammation
15.7(6.1–40.3)
P < 0.001- Major arrhythmic event (MAE) by 60-month follow-up
- 51 patients (15%)
Observational data: associations, not effects.
Further findings
Validation cohort discrimination
- Uno's C-index
- 0.81 (95% CI .75-.88)
Original publication
Major arrhythmias in non-dilated left ventricular cardiomyopathy: a novel prediction score. Eur Heart J. Published 18 July 2025. doi:10.
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