Valvular & structural heart disease
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease
Authors' conclusion
MFSD5 knockdown suppressing human valvular cell Lp(a) uptake and calcification, along with meta-analysis of MFSD5 variants associating with aortic stenosis
Study context
- Population
- Primary human valvular endothelial and interstitial cells; aortic stenosis genetic association
- Comparison
- MFSD5 inhibition vs no inhibition
- Outcome
- Lp(a) uptake and calcification; MFSD5 variants and AS
Methodological detailsligand-receptor capture mass spectrometry, genetic association analysis
- Ligand-receptor capture mass spectrometry
- Genetic association analysis
Main finding
As reported in the abstract
MFSD5 variants associated with AS (after multiple hypothesis testing)
P=0.027
Original publication
Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease. Circulation. Published 8 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it