Valvular & structural heart disease
Aortic valve perivascular adipose tissue computed tomography attenuation in patients with aortic stenosis
Authors' conclusion
CT-derived aortic valve perivascular adipose tissue attenuation is not associated with AS disease severity, activity or progression suggesting that it has no value in the investigation and management of patients with AS.
Study context
- Population
- Patients with and without aortic stenosis (AS) undergoing CT
- Participants
- 120 vs 80
- Exposure
- AS vs controls
- ASn = 120
- Controlsn = 80reference
- Outcome
- Aortic valve perivascular adipose tissue CT attenuation and its association with AS severity, activity and progression
Main finding
As reported in the abstract
Aortic valve perivascular adipose tissue attenuation
AS
−62.4
interval −68.7–-56.5 · Hounsfield units (HU)
Controls
−61.2
interval −65.3–-55.6 · HU
P = 0.099
- No association between baseline attenuation and AS progression (annualised change in peak velocity)
- r=0.072, p=0.458
Observational data: associations, not effects.
Further findings
| Outcome | Mild AS | Moderate AS | Severe AS |
|---|---|---|---|
| Attenuation by AS severity | −60.2 (interval −66.9–-55.1) HU | −62.8 (interval −69.6–-56.80) HU | −62.3 (interval −69.3–-55.4) HU |
- Attenuation by AS severity — No differences between severity groups
- all p>0.05
Interobserver repeatability
- Intraclass correlation coefficient
- 0.977 (95% CI: 0.94, 0.99)
Five other image analysis methods
- Similar results
Original publication
Aortic valve perivascular adipose tissue computed tomography attenuation in patients with aortic stenosis. Heart. Published 2 November 2023. doi:10.
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