Valvular & structural heart disease
Management of asymptomatic severe aortic stenosis: A critical review of guidelines and clinical outcomes
Pooled result · MACEResult — go to the resultHazard ratio 0.52 CI 0.42–0.63Authors' conclusion
While there is broad consensus on classic indicators of severity such as left ventricular dysfunction as indication for intervention, guidelines diverge on other high-risk features warranting intervention.
Study context
- Population
- Asymptomatic severe aortic stenosis (AS)4 guidelines · 108 recommendations
- Comparison
- Early intervention vs clinical surveillance
- Outcome
- MACE
Methodological detailsrandom-effects, comparative matrix of guidelines
- Random-effects
- Comparative matrix of guidelines
Pooled result
MACE
Hazard ratio
0.52
CI 0.42–0.63
Early intervention vs Clinical surveillance
HR 0.52 (CI 0.42–0.63)
As reported in the abstract
Further pooled results
| Outcome | HR (CI) | |
|---|---|---|
| Unplanned hospitalizations | 0.41 (0.32–0.52) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Management of asymptomatic severe aortic stenosis: A critical review of guidelines and clinical outcomes. Am Heart J. Published 15 April 2025. doi:10.
Summarised from the published abstract; every number is checked against it