Arrhythmias & electrophysiology
Management of oral anticoagulation after pulsed field ablation for atrial fibrillation: Insights from a multicenter study
Authors' conclusion
In this consecutive series, no stroke/TIA were reported in the PFA population after discontinuation of OAC at 1 month, whereas a significantly higher number of strokes were documented after OAC interruption at 1 month in the RFA group.
Study context
- Population
- Consecutive patients undergoing pulsed field ablation (PFA) or radiofrequency ablation (RFA) for atrial fibrillation during the same time periodincluded in this analysis · PFA population 400 · RFA population 400
- Participants
- 800 patients
- Comparison
- Different strategies for oral anticoagulation (OAC) management following PFA and RFA
- PFA-group 1n = 196
- PFA-group 2n = 204
- RFA-group 1n = 182
- RFA-group 2n = 218
- Outcome
- Stroke or TIA
- Follow-up
- 15 months
Methodological detailspropensity score matched (1:1), consecutive patients, prospectively followed up for 15 months
- Propensity score matched (1:1)
- Consecutive patients
- Prospectively followed up for 15 months
Main finding
As reported in the abstract
RFA-group 1 vs RFA-group 2: P = 0.017 · PFA population vs RFA cohort: P < 0.001 · PFA population vs RFA-group 1: P < 0.001
- Stroke/transient ischemic attack (TIA) in the RFA cohort
- 23
Further findings
Arrhythmia-recurrence · 15-month
P = 0.003
- Arrhythmia-recurrence: RFA value also printed as "(27.4%)"
Original publication
Management of oral anticoagulation after pulsed field ablation for atrial fibrillation: Insights from a multicenter study. Heart Rhythm. Published 30 July 2025. doi:10.
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