Arrhythmias & electrophysiology
Markers of Atrial Myopathy in the General Population: Prevalence, Predictors, and Inter-Relations
Authors' conclusion
In the general population, indirect markers of atrial myopathy are common but only weakly correlated, and their risk factor patterns are different.
Study context
- Population
- General population without AF with 24-hour ECG (SCAPIS, Sweden)P-wave n = 1,201
- Participants
- 6,013 participants
- Outcome
- Prevalence, clinical correlates and overlap of atrial myopathy markers (≥500 premature atrial complexes/24 h, LAVi ≥34 mL/m², P-wave duration >120 ms, P-wave terminal force in V1 >4,000 ms·s)
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Number of atrial myopathy markers (all modalities available)
≥1 atrial myopathy marker
42%
2 markers
9%
≥3 markers
0.3%
Only P-wave duration and left atrial volume index (LAVi) correlated
ρ = 0.10
P = 0.04
Observational data: associations, not effects.
Further findings
Clinical correlates of premature atrial complexes
- Current smoking
- 34% increase; P < 0.001
- SBP
- 4%/mm Hg increase; P = 0.01
- DM
- 35% increase; P = 0.001
- CAD
- 71% increase; P = 0.003
Clinical correlates of LAVi
- Physical activity ≥2 h/wk associated with increased LAVi
- β-coefficient = 3.1; P < 0.0001
Clinical correlates of P-wave duration
- BMI associated with P-wave duration
- β-coefficient = 0.4/kg/m²; P < 0.0001
Original publication
Markers of Atrial Myopathy in the General Population: Prevalence, Predictors, and Inter-Relations. JACC Clin Electrophysiol. Published 6 September 2023. doi:10.
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