Arrhythmias & electrophysiology
Matching Ablation Endpoints to Long-Term Outcome: The Prospective Multicenter Italian Ventricular Tachycardia Ablation Registry
Authors' conclusion
A standardized VT mapping and ablation technique reproduced the procedural outcomes of a single referral center in a multicenter prospective study. LP abolition and noninducibility were effective in reducing VT recurrences in patients with 4 causes of cardiomyopathy.
Study context
- Population
- Patients undergoing ventricular tachycardia (VT) ablation with 4 causes of VT: previous MI, previous myocarditis, arrhythmogenic right ventricular dysplasia or idiopathic dilated cardiomyopathy
- Participants
- 309 patients
- Outcome
- Freedom from VT (long-term primary efficacy endpoint)
- Follow-up
- 12 months
Main finding
As reported in the abstract
Freedom from VT
Freedom from VT at 12 months
67%
Observational data: associations, not effects.
Further findings
Procedural results (late potential (LPs))
- LPs present
- 70%
- LPs abolished
- 83%
- Noninducible at end of procedure (of LPs)
- 74%
- Combined endpoint of LP abolition and noninducibility achieved (patients with LPs at baseline)
- 64%
Predictors of freedom from VT
- VT inducibility the only predictor (overall)
- P = 0.013
- Lower VT recurrence with complete LP abolition (patients with LPs)
- P = 0.040
- Lower VT recurrence when meeting composite endpoint (patients with LPs)
- P = 0.035
Original publication
Matching Ablation Endpoints to Long-Term Outcome: The Prospective Multicenter Italian Ventricular Tachycardia Ablation Registry. JACC Clin Electrophysiol. Published 18 January 2023. doi:10.
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