Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States
Authors' conclusion
Delivery with history of HT is associated with significantly increased rates of SMM, preterm birth, and hospital readmission.
Study context
- Population
- Delivery hospitalizations in the US, Nationwide Readmissions Database 2010–2020
- Participants
- 19,399,521 deliveries
- Exposure
- Heart transplantation (HT) recipients vs no-HT
- HTn = 105
- Outcome
- SMM, nontransfusion SMM, cardiovascular SMM (cSMM) and preterm birth from delivery hospitalization
Methodological detailsnational database (Nationwide Readmissions Database 2010-2020)
- National database (Nationwide Readmissions Database 2010-2020)
Main finding
As reported in the abstract
All SMM
Nontransfusion SMM
cSMM
Preterm birth
- All four comparisons HT vs No-HT
- P < 0.001
- Adjusted odds of severe maternal morbidity (SMM), HT vs No-HT
- 16-fold greater
- Adjusted odds of nontransfusion SMM, HT vs No-HT
- 28-fold greater
- Adjusted odds of cardiovascular SMM (cSMM), HT vs No-HT
- 38-fold greater
- Adjusted odds of preterm birth, HT vs No-HT
- 7-fold greater
Observational data: associations, not effects.
Further findings
| Outcome | HT | No-HT | Adjusted HR (95% CI) | |
|---|---|---|---|---|
| Readmission · within 1 year following delivery | 26.9% | 3.8% | 6.03 (3.73–9.75) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Original publication
Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States. JACC Heart Fail. Published 4 October 2023. doi:10.
Summarised from the published abstract; every number is checked against it