Matrix metalloproteinase-9 might affect adaptive immunity in non-ST segment elevation acute coronary syndromes by increasing CD31 cleavage on CD4+ T-cells
Authors' conclusion
Our study suggest that enhanced MMP-9 release plays a key role in determining the cleavage and shedding of the functional CD31 domain 1-5 in CD4+ T-cells of ACS patients.
Study context
- Population
- Patients with acute coronary syndrome (ACS), stable angina and controls; CD4+ T-cells analysed by flow cytometry
- Participants
- 30 / 25 / 28
- Comparison
- ACS vs stable angina (SA) vs controls
- ACSn = 30
- SAn = 25
- Controls (CTRL)n = 28reference
- Outcome
- CD31 domain 1-5/domain 6 ratio on CD4+ T-cells (CD31 cleavage)
Main finding
As reported in the abstract
- CD31 domain 1-5/6 ratio significantly lower in ACS vs SA
- P = 0.002
- CD31 domain 1-5/6 ratio significantly lower in ACS vs CTRL
- P = 0.002
- After anti-CD3/CD28 stimulation, 1-5/6 domain ratio significantly lower in ACS vs SA
- P = 0.005
- Higher MMP-9 production by TCR-stimulated CD4+ T-cells in ACS vs SA
- P < 0.001
- CD31 domain 1-5 expression in activated CD4+ T-cells from ACS increased after MMP-9 inhibitor
- P = 0.042
Original publication
Matrix metalloproteinase-9 might affect adaptive immunity in non-ST segment elevation acute coronary syndromes by increasing CD31 cleavage on CD4+ T-cells. Eur Heart J. Published 2 December 2017. doi:10.
Summarised from the published abstract; every number is checked against it