Heart failure & cardiomyopathies
Mechanical Dyssynchrony of Isolated Left and Right Ventricular Human Myocardium in End-Stage Heart Failure
Authors' conclusion
At the level of isolated cardiac trabeculae, contractile performance, specifically of contractile kinetics, is correlated in the nonfailing myocardium between the left and right ventricles' but this correlation is significantly weaker, or even absent, in end-stage heart failure, suggesting an interventricular mechanical dyssynchrony.
Study context
- Population
- Isolated LV and RV trabeculae from nonfailing and end-stage failing human hearts
- Participants
- 41 vs 29
- Comparison
- RV vs LV myocardium; nonfailing vs end-stage failing hearts
- Nonfailingn = 41reference
- Failingn = 29
- Outcome
- LV vs RV contractile properties and LV/RV mechanical synchrony
Main finding
As reported in the abstract
- Failing RV vs LV myocardium: higher developed force (Fdev), d=0.98
- P=0.001
- Failing RV vs LV myocardium: prolonged time to peak, d=1.14
- P<0.001
- Failing RV vs LV myocardium: higher rate of force development, d=0.89
- P=0.002
- Failing RV vs LV myocardium: higher rate of force decline, d=0.82
- P=0.003
- Nonfailing: LV–RV correlation in time to peak, r=0.58
- P<0.001
- Nonfailing: LV–RV correlation in maximal kinetic rate of contraction, r=0.63
- P<0.001
Original publication
Mechanical Dyssynchrony of Isolated Left and Right Ventricular Human Myocardium in End-Stage Heart Failure. Circ Heart Fail. Published 25 January 2023. doi:10.
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