Heart failure & cardiomyopathies
Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium
Authors' conclusion
Failing cardiomyocytes exhibit elevated viscosity and reducing microtubule density or detyrosination lowers viscoelastic resistance to diastolic stretch in human myocytes and myocardium.
Study context
- Population
- Isolated human cardiomyocytes from nonfailing and heart failure (HF) hearts; LV trabeculae from HF patient hearts
- Comparison
- Microtubule-targeting interventions (incl. colchicine) vs vehicle in failing human cardiomyocytes and myocardium
- Outcome
- Viscoelasticity during diastolic stretch
Main finding
As reported in the abstract
Reduction in energy dissipation upon microtubule depolymerization
2-fold
Further findings
- HFrEF myocardium more fibrotic and elastic; HFpEF relatively more viscous
- Colchicine reduced viscoelasticity in both HFpEF and HFrEF myocardium
- Post hoc subgroup analysis
Original publication
Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. Circulation. Published 16 January 2020. doi:10.
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