Mechanisms of Myocardial Reverse Remodelling and Its Clinical Significance: A Scientific Statement of the ESC Working Group on Myocardial Function

Cardiac RR is defined as any normative improvement in cardiac geometry and function, driven by therapeutic interventions and rarely occurring spontaneously

Interventions triggering RR depend on the myocardial insult: drugs (renin-angiotensin-aldosterone system inhibitors, beta-blockers, diuretics, SGLT2 inhibitors), devices (CRT, ventricular assist devices), surgeries (valve replacement, CABG) or physiological responses (deconditioning, postpartum)

RR is inferred from normalization of LV mass, EF and end-diastolic/end-systolic volumes, whose extent often correlates with prognosis