Heart failure & cardiomyopathiesCohort study
Prognosis and treatment strategies for atrial fibrillation in heart failure with mildly reduced ejection fraction
- Retrospective cohort study
- single-centre
- propensity-score matched
Authors' conclusion
Atrial fibrillation affects 43% of patients with HFmrEF and represents an independent predictor of adverse long-term prognosis.
Study context
- Population
- Consecutive patients with heart failure with mildly reduced ejection fraction (HFmrEF) (LVEF 41–49% and signs and/or symptoms of heart failure (HF)), one institution, 2016 to 2022Atrial fibrillation (AF) prevalence 43%
- Participants
- 2,148 patients
- Exposure
- AF vs no AF
- Outcome
- All-cause mortality and HF-related rehospitalization
- Follow-up
- 30 months (median )
Main finding
As reported in the abstract
30 months
AF vs No AFHazard ratio (95% CI)P value
AF
2.068(1.802–2.375)
P = 0.01after propensity score matching
1.494(1.216–1.835)
P = 0.01Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · independent predictor | 1.340 (1.066–1.685) | P = 0.01 | |
| HF-related rehospitalization · independent predictor | 2.061 (1.538–2.696) | P = 0.01 | |
| All-cause mortality, rhythm vs rate control for AF · may be associated with lower risk | 0.342 (0.199–0.587) | P = 0.01 | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Prognosis and treatment strategies for atrial fibrillation in heart failure with mildly reduced ejection fraction. Eur J Prev Cardiol. Published 3 June 2024. doi:10.1093/eurjpc/zwae185
Summarised from the published abstract; every number is checked against it